HIPEC Surgery


ABOUT HIPEC

Cytoreductive surgery (CRS) and heated or hyperthermic intraperitoneal chemotherapy (HIPEC) is a multimodal treatment plan that has significantly improved survival for peritoneal cancer and mesothelioma patients. This procedure can be performed for cancers of abdomen and chest (thorax). The procedure is called HITOC when it is performed for chest, however, the principle remains the same. This procedure can be performed by laparoscopy in selected patients, reducing the trauma and enhancing the recovery.

ADVANTAGES OF HIPEC OVER TRADITIONAL CHEMOTHERAPY

  • Traditional chemotherapy has little or no effect on these peritoneal cancers.
  • The HIPEC procedure is developed to improve the relatively poor results of traditional chemotherapy treatment.
  • Although many patients respond well to unheated chemotherapy drugs, the effects are often short-lived.
  • Heating is known to increase the effectiveness of chemotherapy.
  • As HIPEC is given directly on to the cancer, a high dose of chemotherapy can be given avoiding the dose to rest of the body.
  • The average survival was around six months before HIPEC became available. At present half of patients who qualify for HIPEC surgery live longer than five years. That is a huge difference in survival.

WHAT ARE THE KINDS OF CANCER THAT CAN BE TREATED WITH HIPEC?

The most common tumors treated by HIPEC are:

  • Colorectal cancers
  • Appendix tumors such as
  • Pseudomyxoma peritonei
  • Low-grade appendiceal mucinous neoplasm

Other cancers treated by HIPEC are:

  • Mesothelioma
  • Adrenal cancer
  • Ovarian cancer
  • Liver cancer
  • Pancreatic cancer

HOW THE HIPEC MACHINE WORKS?

  • Surgeons place tubes into the abdominal cavity and connect them to the perfusion system, which heats the chemotherapy solution and pumps it to and from the body.
  • As the solution flows through the machine, a heating element raises it to between to about 40 to 42C. Cancer cells start to die when heated to around this temparature, while normal cells can survive up to 43.9C.
  • A doctor massages the abdomen by hand or mixes the liquid regularly to ensure the solution is fully mixed. This step helps the drugs reach remaining cancer cells.
  • This process continues for about 60 to 90 min.
  • When this is finished, surgeons drain the medicated solution from the body.
  • The cavity is rinsed with only a saline solution to clear all the drugs before the catheter is removed and incision is closed.

The entire procedure, including CRS and HIPEC, may take between 6 and 12 hours to complete based on the amount of cancer. The more the cancer has spread within the abdomen, the longer surgery will take.

RECOVERY

HIPEC is a major procedure and after this surgery, you should expect a recovery time of several months. Your treatment team will go over everything you need to know about the recovery process, including how to care for your incision wounds and encourage healing.

The most difficult aspect of recovery is fatigue. It will likely take two to three months until you begin to feel back to normal again. Until then, it is important to follow the advise on nutrition and stay active.

Call Us

Appointment